The Osam is a river in north Bulgaria, with a length of 314 km and a catchment area of 2 820 km². The river takes its source from the foot of Levski Peak in Stara Planina, at an altitude of 1 821 m. The Osam flows into the river Danube near the town of Nikopol. The ancient name of the river was Assamus.

Towns in the valley of the Osam include Lovech, Troyan, Letnitsa, Levski and Nikopol.

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